Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase.

International journal of molecular medicine - 1 Dec 2011

Khan Zahidul, Akhtar Monira, Ekström Tomas J

Abstract excerpt

Cell replacement and gene therapy using neural stem cells (NSCs) have been widely touted as a promising treatment for CNS diseases including brain tumors. Histone deacetylase (HDAC) inhibitors have been used to explore mechanisms behind the lineage-specific differentiation of NSCs and as modulators of gene therapy. We have used the human embryonic midbrain stem cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methyltransferase 3B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glial Fibrillary Acidic Protein

Share to Histone Deacetylase Inhibitors

Share to Mesencephalon

Share to Nestin

Share to Phenylbutyrates

Share to Stem Cell Transplantation

Source

Identifiers

PMID: 21894430
DOI: 10.3892/ijmm.2011.791

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase.PMID 21894430Read ↗

Epigenetic conversion of human adult bone mesodermal stromal cells into neuroectodermal cell types for replacement therapy of neurodegenerative disordersSemantic proximity Read ↗

Irradiation and lithium treatment alter the global DNA methylation pattern and gene expression underlying a shift from gliogenesis towards neurogenesis in human neural progenitorsSemantic proximity Read ↗

DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells.Semantic proximity Read ↗

Epigenetic modulation of dental pulp stem cells: implications for regenerative endodonticsSemantic proximity Read ↗

Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma NeurospheresSemantic proximity Read ↗

RG108 increases NANOG and OCT4 in bone marrow-derived mesenchymal cells through global changes in DNA modifications and epigenetic activationSemantic proximity Read ↗

BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cellsSemantic proximity Read ↗

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndromeSemantic proximity Read ↗

Dynamics of 5-carboxylcytosine during hepatic differentiation: Potential general role for active demethylation by DNA repair in lineage specificationSemantic proximity Read ↗

Investigating DNA methylation dynamics and safety of human embryonic stem cell differentiation toward striatal neurons.Semantic proximity Read ↗

Bone morphogenetic protein 4 reduces global H3K4me3 to inhibit proliferation and promote differentiation of human neural stem cellsSemantic proximity Read ↗

A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.