Article
Variations in the promoter region of the glutaminase gene and the development of hepatic encephalopathy in patients with cirrhosis: a cohort study.
Annals of internal medicine - 7 Sept 2010
Romero-Gómez Manuel, Jover María, Del Campo José A, Royo José L, Hoyas Elena, Galán José J, Montoliu Carmina, Baccaro Eugenia, Guevara Mónica, Córdoba Juan, Soriano Germán, Navarro José M, Martínez-Sierra Carmen, Grande Lourdes, Galindo Antonio, Mira Emilia, Mañes Santos, Ruiz Agustín
Abstract excerpt
BACKGROUND: Hepatic encephalopathy is a major complication of cirrhosis and is associated with a poor prognosis. OBJECTIVE: To identify mutations in the gene sequence for glutaminase in humans that could be responsible for the development of hepatic encephalopathy in patients with cirrhosis. DESIGN: Cohort study. SETTING: Outpatient clinics in 6 Spanish hospitals. PATIENTS: 109 consecutive patients with cirrhosis...
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