Article
Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men.
Neurology - 7 Sept 2010
Panizzon M S, Hauger R, Dale A M, Eaves L J, Eyler L T, Fischl B, Fennema-Notestine C, Franz C E, Grant M D, Jak A J, Jacobson K C, Lyons M J, Mendoza S P, Neale M C, Prom-Wormley E C, Seidman L J, Tsuang M T, Xian H, Kremen W S
Abstract excerpt
BACKGROUND: The APOE epsilon4 allele is an established risk factor for Alzheimer disease (AD), yet findings are mixed for how early its effects are manifest. One reason for the mixed results could be the presence of interaction effects with other AD risk factors. Increasing evidence indicates that testosterone may play a significant role in the development of AD. The aim of the present study was to examine the...
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