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Article

NPHP proteins: gatekeepers of the ciliary compartment.

The Journal of cell biology - 6 Sept 2010

Omran Heymut

Abstract excerpt

The cilia and the cytoplasm are separated by a region called the transition zone, where wedge-shaped structures link the microtubule doublets of the axoneme to the ciliary membrane, thereby forming a ciliary "gate." In this issue, Craige et al. (J. Cell Biol. doi:10.1083/jcb.201006105) demonstrate in Chlamydomonas reinhardtii that Nphp6/cep290, which is mutated in nephronophthisis (NPHP), is an integral component...

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Identifiers

PMID: 20819931
DOI: 10.1083/jcb.201008080
PMCID: PMC2935579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

NPHP proteins: gatekeepers of the ciliary compartment.PMID 20819931Read ↗

Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone.Semantic proximity Read ↗

Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zoneSemantic proximity Read ↗

Ciliary transition zone proteins coordinate ciliary protein composition and ectosome sheddingSemantic proximity Read ↗

The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure.Semantic proximity Read ↗

Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity.Semantic proximity Read ↗

Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo deliverySemantic proximity Read ↗

The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate.Semantic proximity Read ↗

CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content.Semantic proximity Read ↗

Nephrocystin Specifically Localizes to the Transition Zone of Renal and Respiratory Cilia and Photoreceptor Connecting CiliaSemantic proximity Read ↗

Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance.Semantic proximity Read ↗

The ciliary transition zone: from morphology and molecules to medicine.Semantic proximity Read ↗

Ciliopathy-associated protein, CEP290, is required for ciliary necklace and outer segment membrane formation in retinal photoreceptorsSemantic proximity Read ↗

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