Article
Angiotensin-converting enzyme gene I/D genotype affected metoprolol-induced reduction in 24-hour average heart rate.
Chinese medical journal - 1 Jun 2010
Liu Li-wei, Liu Hong, Chen Guo-Liang, Huang Yi-ling, Han Lu-lu, Xu Zhi-min, Jiang Xiong-jing, Li Yi-shi
Abstract excerpt
BACKGROUND: Genetic factors can influence antihypertensive response to metoprolol, and many studies focused on the relationship between the genotype in beta1-adrenergic receptor and blood pressure (BP), little was known about the association of angiotensin-converting enzyme (ACE) genotype with the therapeutic result of metoprolol. The present study aimed to investigate whether the ACE gene insertion (I)/deletion...
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