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Article

An acute negative bystander effect of γ-irradiated recipients on transplanted hematopoietic stem cells

29 Feb 2012

Abstract excerpt

Ultimate success of hematopoietic stem cell transplantation (HSCT) depends not only on donor HSCs themselves but also on the host environment. Total body irradiation is a component in various host conditioning regimens for HSCT. It is known that ionizing radiation exerts "bystander effects" on nontargeted cells and that HSCs transplanted into irradiated recipients undergo proliferative exhaustion. However,...

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PMID: 22374698
DOI: 10.1182/blood-2011-08-373621

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