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Article

The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk.

Oncology reports - 1 Oct 2010

Gomes Bruno Costa, Silva Susana Nunes, Azevedo Ana Paula, Manita Isabel, Gil Octávia Monteiro, Ferreira Teresa Cruz, Limbert Edward, Rueff José, Gaspar Jorge Francisco

Abstract excerpt

Variations, such as single nucleotide polymorphisms (SNPs) in DNA damage repair genes have been pointed out as possible factors to cancer predisposition. Ionizing radiation (IR) induces DNA double strand breaks (DSBs) and is the main recognized risk factor for thyroid cancer. However, most of the patients do not show chronic contact with IR and the other factors have non-concordant data. Thus, thyroid cancer...

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Source

Identifiers

PMID: 20811692

Genes

LIG4
XRCC4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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