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Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner

13 Dec 2018

Abstract excerpt

Urinary tract infections (UTI) are extremely common and can be highly recurrent, with 1-2% of women suffering from six or more recurrent episodes per year. The high incidence of recurrent UTI, including recurrent infections caused by the same bacterial strain that caused the first infection, suggests that at least some women do not mount a protective adaptive immune response to UTI. Here we observed in a mouse...

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PMID: 30543708
DOI: 10.1371/journal.ppat.1007457

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