Article
Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome.
PloS one - 27 Aug 2010
Antczak Philipp, Ortega Fernando, Chipman J Kevin, Falciani Francesco
Abstract excerpt
The identification of predictive biomarkers is at the core of modern toxicology. So far, a number of approaches have been proposed. These rely on statistical inference of toxicity response from either compound features (i.e., QSAR), in vitro cell based assays or molecular profiling of target tissues (i.e., expression profiling). Although these approaches have already shown the potential of predictive toxicology,...
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