Article
Functional analysis of multiple genomic signatures demonstrates that classification algorithms choose phenotype-related genes.
The pharmacogenomics journal - 1 Aug 2010
Shi W, Bessarabova M, Dosymbekov D, Dezso Z, Nikolskaya T, Dudoladova M, Serebryiskaya T, Bugrim A, Guryanov A, Brennan R J, Shah R, Dopazo J, Chen M, Deng Y, Shi T, Jurman G, Furlanello C, Thomas R S, Corton J C, Tong W, Shi L, Nikolsky Y
Abstract excerpt
Gene expression signatures of toxicity and clinical response benefit both safety assessment and clinical practice; however, difficulties in connecting signature genes with the predicted end points have limited their application. The Microarray Quality Control Consortium II (MAQCII) project generated 262 signatures for ten clinical and three toxicological end points from six gene expression data sets, an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.