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Article

Variability of the polymerase gene (NS5B) in hepatitis C virus-infected women.

Journal of clinical microbiology - 1 Nov 2010

Blackard Jason T, Ma Gang, Limketkai Berkeley N, Welge Jeffrey A, Dryer Peter D, Martin Christina M, Hiasa Yoichi, Taylor Lynn E, Mayer Kenneth H, Jamieson Denise J, Sherman Kenneth E

Abstract excerpt

There are limited data on diversity within the hepatitis C virus polymerase (NS5B). In concordance with its key functional role during the life cycle, NS5B intrapatient variability was low. Moreover, differences between NS5B nonsynonymous (dN) and synonymous (dS) mutation rates (dN - dS) were positively correlated with CD4 cell count, while nonsynonymous mutations were strongly correlated with reduced replication...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20810773
DOI: 10.1128/JCM.01613-10
PMCID: PMC3020841

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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