Article
Association between hsa-mir-146a genotype and tumor age-of-onset in BRCA1/BRCA2-negative familial breast and ovarian cancer patients.
Carcinogenesis - 1 Dec 2010
Pastrello Chiara, Polesel Jerry, Della Puppa Lara, Viel Alessandra, Maestro Roberta
Abstract excerpt
An increasing body of evidence points to a possible role of microRNAs (miRNAs) in hereditary cancer syndromes. To evaluate the role of miRNA allelic variants in the susceptibility to familial breast and ovarian cancers in BRCA1/BRCA2-negative patients, we focused our attention on three miRNAs, miR-146a, miR-17 and miR-369, based on their affinity to either BRCA1 or BRCA2 messenger RNA and their localization on...
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