Article
The rs2910164:G>C SNP in the MIR146A gene is not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Human mutation - 1 Sept 2011
Garcia Amandine I, Cox David G, Barjhoux Laure, Verny-Pierre Carole, Barnes Daniel, Antoniou Antonis C, Stoppa-Lyonnet Dominique, Sinilnikova Olga M, Mazoyer Sylvie
Abstract excerpt
The rs2910164:G>C SNP is located in the gene for miR-146a, a microRNA that binds the 3' UTR of the BRCA1 transcript. Preliminary data based on the analysis of a small number of cases suggested that this single nucleotide polymorphism (SNP) might be associated with the age of onset of familial breast and ovarian cancer. This effect was not confirmed on a large series of familial breast cancer cases negative for a...
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