Article
Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases.
Human mutation - 1 Jan 2010
Catucci Irene, Yang Rongxi, Verderio Paolo, Pizzamiglio Sara, Heesen Ludwig, Hemminki Kari, Sutter Christian, Wappenschmidt Barbara, Dick Michelle, Arnold Norbert, Bugert Peter, Niederacher Dieter, Meindl Alfons, Schmutzler Rita K, Bartram Claus C, Ficarazzi Filomena, Tizzoni Laura, Zaffaroni Daniela, Manoukian Siranoush, Barile Monica, Pierotti Marco A, Radice Paolo, Burwinkel Barbara, Peterlongo Paolo
Abstract excerpt
Recently, the SNPs rs11614913 in hsa-mir-196a2 and rs3746444 in hsa-mir-499 were reported to be associated with increased breast cancer risk, and the SNP rs2910164 in hsa-mir-146a was shown to have an effect on age of breast cancer diagnosis. In order to further investigate the effect of these SNPs, we genotyped a total of 1894 breast cancer cases negative for disease-causing mutations or unclassified variants in...
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