Article
Contribution of herpesvirus specific CD8 T cells to anti-viral T cell response in humans.
PLoS pathogens - 19 Aug 2010
Sandalova Elena, Laccabue Diletta, Boni Carolina, Tan Anthony T, Fink Katja, Ooi Eng Eong, Chua Robert, Shafaeddin Schreve Bahar, Ferrari Carlo, Bertoletti Antonio
Abstract excerpt
Herpesviruses infect most humans. Their infections can be associated with pathological conditions and significant changes in T cell repertoire but evidences of symbiotic effects of herpesvirus latency have never been demonstrated. We tested the hypothesis that HCMV and EBV-specific CD8 T cells contribute to the heterologous anti-viral immune response. Volume of activated/proliferating virus-specific and total CD8...
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