Article
Competing activities of heterotrimeric G proteins in Drosophila wing maturation.
PloS one - 23 Aug 2010
Katanayeva Natalya, Kopein Damir, Portmann Reto, Hess Daniel, Katanaev Vladimir L
Abstract excerpt
Drosophila genome encodes six alpha-subunits of heterotrimeric G proteins. The Galphas alpha-subunit is involved in the post-eclosion wing maturation, which consists of the epithelial-mesenchymal transition and cell death, accompanied by unfolding of the pupal wing into the firm adult flight organ. Here we show that another alpha-subunit Galphao can specifically antagonize the Galphas activities by competing for...
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