Article
Anti-influenza virus activity of the compound LY253963.
Antiviral research - 1 Jul 1990
Hayden F G, Rollins B S, Hay A J
Abstract excerpt
The compound LY253963 (1,3,4-thiadiazol-2-ylcyanamide) inhibited the in vitro replication of representative influenza A and B viruses in Madin-Darby canine kidney (MDCK) cells at concentrations of 1-3.2 micrograms/ml. The yield of an influenza A (H3N2) virus in primary rhesus monkey kidney (RMK) cells was inhibited at 0.1-0.3 micrograms/ml. However, similar concentrations were inhibitory for the growth of...
Topics
- Antiviral Agents
- Cells, Cultured
- Drug Resistance, Microbial
- Drug Therapy, Combination
- Influenza A virus
- Influenza B virus
- Microbial Sensitivity Tests
- Mutation
- Nitriles
- Orthomyxoviridae
- RNA, Messenger