Article
Characterization of novel respiratory syncytial virus inhibitors identified by high throughput screen.
Antiviral research - 1 Mar 2015
Laganas Valerie A, Dunn Ewan F, McLaughlin Robert E, Tiong-Yip Choi Lai, Yuzhakov Olga, Isabella Vincent M, Hill Pamela, Yu Qin
Abstract excerpt
Respiratory Syncytial Virus (RSV) is a major cause of lower respiratory tract infections with no effective treatment available. Finding novel inhibitors of RSV is an important first step towards developing an efficacious RSV therapy. Here we report the characterization of three novel classes of RSV replication inhibitors identified through a high throughput RSV replicon screen of ∼1million compounds in the...
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