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Discovery of a Novel Respiratory Syncytial Virus Replication Inhibitor

30 Mar 2021

Abstract excerpt

) values of approximately 1 μM, but it was not effective against other viruses, including influenza virus A, human enterovirus 71 (EV71), and vaccinia virus. Triazole-1 was shown to inhibit RSV replication when added at up to 8 h after viral entry, suggesting that it inhibits RSV after viral entry. In a minigenome reporter assay in which RSV transcription regulatory sequences flanking a luciferase gene were...

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PMID: 33782012
DOI: 10.1128/aac.02576-20

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