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Article

Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3(+) precursors and impaired activated population.

Journal of autoimmunity - 1 Dec 2010

Laakso Sini M, Laurinolli Tuisku-Tuulia, Rossi Laura H, Lehtoviita Anni, Sairanen Heikki, Perheentupa Jaakko, Kekäläinen Eliisa, Arstila T Petteri

Abstract excerpt

The pathogenetic mechanisms of organ-specific autoimmune diseases remain obscured by the complexity of the genetic and environmental factors participating in the breakdown of tolerance. A unique opportunity to study the pathogenesis of human autoimmunity is provided by autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), a rare inherited autoimmune disease caused by mutations in Autoimmune...

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Source

Identifiers

PMID: 20805020
DOI: 10.1016/j.jaut.2010.07.008

Genes

AIRE
FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3(+) precursors and impaired activated population.PMID 20805020Read ↗

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