Article
Prediction of deleterious non-synonymous single nucleotide polymorphisms of genes related to ethanol-induced toxicity.
Toxicology letters - 1 Jun 2009
Wang Lin-Lin, Li Yong, Zhou Shu-Feng
Abstract excerpt
Non-synonymous single nucleotide polymorphisms (nsSNPs) that cause amino acid changes are believed to have a large impact on protein function. It is important to distinguish those deleterious nsSNPs that affect protein function from those that are functionally neutral. Ethanol causes organ toxicity with involvement of a number of genes encoding functional proteins. We have identified 1509 alcohol-responsive genes...
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