Evidence based on studies of the mus309 mutant, deficient in DNA double-strand break repair, that meiotic crossing over in Drosophila melanogaster is a two-phase process.

Abstract excerpt

The mus309 gene in Drosophila melanogaster encodes a RecQ helicase which is involved in DNA double-strand break (DSB) repair and specifically in the choice between the different pathways of the repair. In a brood pattern analysis of mus309 and wild type females which either had or had not experienced a temperature shock, different parameters of meiotic crossing over including map distances and crossover...

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