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Article

PCSK5 and GDF11 Expression in the Hindgut Region of Mouse Embryos with Anorectal Malformations

8 Apr 2011

Abstract excerpt

BACKGROUND/PURPOSE: Retinoid-mediated signal transduction plays a crucial role in the embryonic development of various organs. We previously reported that retinoic acid induced anorectal malformations (ARM) in mice. GDF11 is a TGFβ superfamily molecule and is cleaved and activated by proprotein convertase subtilisin/kexin 5 (PCSK5). PCSK5 (PC5/6) mutations result in an abnormal expression of Hlxb9 and Hox genes,...

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PMID: 21480163
DOI: 10.1055/s-0031-1273691

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