Article
Decreased levels of embryonic retinoic acid synthesis accelerate recovery from arterial growth delay in a mouse model of DiGeorge syndrome.
Circulation research - 5 Mar 2010
Ryckebüsch Lucile, Bertrand Nicolas, Mesbah Karim, Bajolle Fanny, Niederreither Karen, Kelly Robert G, Zaffran Stéphane
Abstract excerpt
RATIONALE: Loss of Tbx1 and decrease of retinoic acid (RA) synthesis result in DiGeorge/velocardiofacial syndrome (DGS/VCFS)-like phenotypes in mouse models, including defects in septation of the outflow tract of the heart and anomalies of pharyngeal arch-derived structures including arteries of the head and neck, laryngeal-tracheal cartilage, and thymus/parathyroid. Wild-type levels of T-box transcription factor...
Topics
- Aldehyde Oxidoreductases
- Animals
- Aorta, Thoracic
- Branchial Region
- Cell Differentiation
- Crosses, Genetic
- DiGeorge Syndrome
- Disease Models, Animal
- Down-Regulation
- Embryo, Mammalian
- Gene Expression Regulation, Developmental
- Genotype