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Article

Decreased levels of embryonic retinoic acid synthesis accelerate recovery from arterial growth delay in a mouse model of DiGeorge syndrome.

Circulation research - 5 Mar 2010

Ryckebüsch Lucile, Bertrand Nicolas, Mesbah Karim, Bajolle Fanny, Niederreither Karen, Kelly Robert G, Zaffran Stéphane

Abstract excerpt

RATIONALE: Loss of Tbx1 and decrease of retinoic acid (RA) synthesis result in DiGeorge/velocardiofacial syndrome (DGS/VCFS)-like phenotypes in mouse models, including defects in septation of the outflow tract of the heart and anomalies of pharyngeal arch-derived structures including arteries of the head and neck, laryngeal-tracheal cartilage, and thymus/parathyroid. Wild-type levels of T-box transcription factor...

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Identifiers

PMID: 20110535
DOI: 10.1161/CIRCRESAHA.109.205732
PMCID: PMC2864540

Genes

SHF

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Research trail→

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Decreased levels of embryonic retinoic acid synthesis accelerate recovery from arterial growth delay in a mouse model of DiGeorge syndrome.PMID 20110535Read ↗

Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice.Semantic proximity Read ↗

22q11 deletion syndrome: a role for TBX1 in pharyngeal and cardiovascular development.Semantic proximity Read ↗

TBX1, a DiGeorge syndrome candidate gene, is inhibited by retinoic acid.Semantic proximity Read ↗

The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system.Semantic proximity Read ↗

Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo.Semantic proximity Read ↗

Tbx1 genetically interacts with the transforming growth factor-β/bone morphogenetic protein inhibitor Smad7 during great vessel remodeling.Semantic proximity Read ↗

T-box genes and retinoic acid signaling regulate the segregation of arterial and venous pole progenitor cells in the murine second heart fieldSemantic proximity Read ↗

22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development.Semantic proximity Read ↗

Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns.Semantic proximity Read ↗

Cyp26 Enzymes Facilitate Second Heart Field Progenitor Addition and Maintenance of Ventricular IntegritySemantic proximity Read ↗

Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis.Semantic proximity Read ↗

Recovery from arterial growth delay reduces penetrance of cardiovascular defects in mice deleted for the DiGeorge syndrome region.Semantic proximity Read ↗

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