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Article

HLA class I allele associations with HCV genetic variants in patients with chronic HCV genotypes 1a or 1b infection.

Journal of hepatology - 1 Dec 2010

Lange Christian Markus, Roomp Kirsten, Dragan Anette, Nattermann Jacob, Michalk Monika, Spengler Ulrich, Weich Viola, Lengauer Thomas, Zeuzem Stefan, Berg Thomas, Sarrazin Christoph

Abstract excerpt

BACKGROUND & AIMS: The adaptive immune response against hepatitis C virus (HCV) is significantly shaped by the host's composition of HLA-alleles with the consequence that the HLA phenotype is a critical determinant of viral evolution during adaptive immune pressure. In the present study, we aimed to identify associations of HLA class I alleles with HCV subtypes 1a and 1b genetic variants. METHODS: The association...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20800922
DOI: 10.1016/j.jhep.2010.06.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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