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Article

Notch3 gene amplification in ovarian cancer.

Cancer research - 15 Jun 2006

Park Joon T, Li Mei, Nakayama Kentaro, Mao Tsui-Lien, Davidson Ben, Zhang Zhen, Kurman Robert J, Eberhart Charles G, Shih Ie-Ming, Wang Tian-Li

Abstract excerpt

Gene amplification is one of the common mechanisms that activate oncogenes. In this study, we used single nucleotide polymorphism array to analyze genome-wide DNA copy number alterations in 31 high-grade ovarian serous carcinomas, the most lethal gynecologic neoplastic disease in women. We identified an amplicon at 19p13.12 in 6 of 31 (19.5%) ovarian high-grade serous carcinomas. This amplification was validated...

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Share to Chromosomes, Human, Pair 19
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to In Situ Hybridization, Fluorescence

Share to Ovarian Neoplasms

Share to Receptor, Notch3

Share to Receptors, Notch

Share to RNA, Small Interfering

Source

Identifiers

PMID: 16778208
DOI: 10.1158/0008-5472.CAN-05-3610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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