Article
Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased risk of micro- and macro-albuminuria and progression of diabetic nephropathy among Iranians with type 2 diabetes mellitus.
Clinical biochemistry - 1 Nov 2010
Rahimi Mehrali, Hasanvand Ali, Rahimi Zohreh, Vaisi-Raygani Asad, Mozafari Hadi, Rezaei Mansour, Zargooshi Javad, Najafi Farid, Shakiba Ebrahim
Abstract excerpt
OBJECTIVES: To find whether polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C are risk factors for diabetic nephropathy (DN) among type 2 diabetes mellitus (T2DM) patients from Western Iran. DESIGN AND METHODS: The MTHFR polymorphisms were detected in 72 microalbuminuric, 68 macroalbuminuric and 72 normoalbuinuric T2DM patients by PCR-RFLP. RESULTS: The possession of both MTHFR 677T...
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