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Article

Mechanisms of human immunodeficiency virus type 1 concerted integration related to strand transfer inhibition and drug resistance.

Antimicrobial agents and chemotherapy - 1 Sept 2008

Zahm Jacob A, Bera Sibes, Pandey Krishan K, Vora Ajaykumar, Stillmock Kara, Hazuda Daria, Grandgenett Duane P

Abstract excerpt

The "strand transfer inhibitors" of human immunodeficiency virus type-1 (HIV-1) integrase (IN), so named because of their pronounced selectivity for inhibiting strand transfer over 3' OH processing, block virus replication in vivo and ex vivo and prevent concerted integration in vitro. We explored the kinetics of product formation and strand transfer inhibition within reconstituted synaptic complexes capable of...

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Identifiers

PMID: 18591263
DOI: 10.1128/AAC.00271-08
PMCID: PMC2533447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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