Article
Functional characterization of the small heat shock protein Hsp12p from Candida albicans.
PloS one - 1 Jan 2012
Fu Man-Shun, De Sordi Luisa, Mühlschlegel Fritz A
Abstract excerpt
Hsp12p is considered to be a small heat shock protein and conserved among fungal species. To investigate the expression of this heat shock protein in the fungal pathogen Candida albicans we developed an anti-CaHsp12p antibody. We show that this protein is induced during stationary phase growth and under stress conditions including heat shock, osmotic, oxidative and heavy metal stress. Furthermore, we find that...
Topics
- Antifungal Agents
- Azoles
- Candida albicans
- Codon, Initiator
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- Farnesol
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Heat-Shock Proteins, Small
- Heat-Shock Response
- Mutation
- Osmotic Pressure