Article
Rapid ribosomal translocation depends on the conserved 18-55 base pair in P-site transfer RNA.
Nature structural & molecular biology - 1 Apr 2006
Pan Dongli, Kirillov Stanislav, Zhang Chun-Mei, Hou Ya-Ming, Cooperman Barry S
Abstract excerpt
The L shape of tRNA is stabilized by the 'tertiary core' region, which contains base-pairing interactions between the D and T loops. Distortions of the L shape accompany tRNA movement across the ribosomal surface. Here, using single-turnover rapid kinetics assays, we determine the effects of mutations within the tertiary core of P site-bound tRNA(fMet) on three measures of the rate of translocation, the part of...
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