Article
Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes.
Molecular biology of the cell - 15 Oct 2010
Vinh Dani B N, Ko Dennis C, Rachubinski Richard A, Aitchison John D, Miller Samuel I
Abstract excerpt
The Salmonella typhimurium effector protein SifA regulates the assembly and tubulation of the Salmonella phagosome. SifA localizes to the phagosome and interacts with the membrane via its prenylated tail. SifA is a structural homologue of another bacterial effector that acts as a GTP-exchange factor for Rho family GTPases and can bind GDP-RhoA. When coexpressed with a bacterial lipase that is activated by RhoA,...
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