Article
Human cytomegalovirus-specific CD8(+) T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects.
Immunology - 1 Jan 2011
Wallace Diana L, Masters Joanne E, De Lara Catherine M, Henson Sian M, Worth Andrew, Zhang Yan, Kumar Shikha R, Beverley Peter C, Akbar Arne N, Macallan Derek C
Abstract excerpt
The immune response to human cytomegalovirus (HCMV) infection is characterized by the accumulation of HCMV-specific CD8(+) T cells, particularly in the elderly; such expansions may impair immune responses to other pathogens. We investigated mechanisms underlying HCMV-specific expansions in 12 you...
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