Article
Reproducibility and performance of virtual karyotyping with SNP microarrays for the detection of chromosomal imbalances in formalin-fixed paraffin-embedded tissues.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Sept 2010
Alvarez Karla, Kash Shera F, Lyons-Weiler Maureen A, Kim Hyun-Jung, Peterson Leif E, Mathai Benita, Hagenkord Jill M, Monzon Federico A
Abstract excerpt
BACKGROUND: Chromosomal imbalances are commonly seen in cancer and inherited genetic diseases. These imbalances may assist in the diagnosis, prognosis, and/or therapeutic management of certain neoplasms. Several methods for detecting chromosomal imbalances, such as, fluorescent in situ hybridization, array comparative genomic hybridization, and single nucleotide polymorphism (SNP) arrays have proven useful in...
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