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Article

Gefitinib radiosensitizes non-small cell lung cancer cells through inhibition of ataxia telangiectasia mutated

23 Aug 2010

Abstract excerpt

PURPOSE: Inhibitors of epidermal growth factor receptor (EGFR) have shown dramatic results in a subset of patients with non-small cell lung cancer (NSCLC), and have also been shown to enhance the effect of ionizing radiation (IR). We investigated how gefitinib, an orally given EGFR inhibitor for NSCLC patients, can radiosensitize NSCLC cells. EXPERIMENTAL DESIGN AND RESULTS: In clonogenic survival assays...

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Share to Cytokine Signaling Pathways and Interactions
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PMID: 20731837
DOI: 10.1186/1476-4598-9-222

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