5-aminolaevulinic acid/photo-dynamic therapy and gefitinib in non-small cell lung cancer cell lines: a potential strategy to improve gefitinib therapeutic efficacy.

doi:10.1111/cpr.12040

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Article

5-aminolaevulinic acid/photo-dynamic therapy and gefitinib in non-small cell lung cancer cell lines: a potential strategy to improve gefitinib therapeutic efficacy.

Cell proliferation - 1 Aug 2013

Postiglione I, Chiaviello A, Aloj S M, Palumbo G

Abstract excerpt

OBJECTIVES: Often, non-small cell lung cancers (NSCLC) respond only poorly to the tyrosine kinase inhibitor (TKI) gefitinib, which targets the epidermal growth factor receptor (EGFR), these poor responders EGFRs lacking activating mutations. In this study, we have attempted to improve TKI response of NSCLC cell lines (A549 and H1299) devoid of EGFR mutations, by combination of gefitinib and 5-ALA/photodynamic...

Topics

Aminolevulinic Acid
Antineoplastic Agents
Carcinoma, Non-Small-Cell Lung
Cell Cycle
Cell Death
Cell Line, Tumor
Cell Proliferation
Cell Survival
ErbB Receptors
Gefitinib
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lung Neoplasms

Mutation

NF-kappa B

Photochemotherapy

Photosensitizing Agents

Proteasome Endopeptidase Complex

Protein Kinase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 23869760
DOI: 10.1111/cpr.12040
PMCID: PMC6622218

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23869760-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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