Article
Tumorigenic WAP-T mouse mammary carcinoma cells: a model for a self-reproducing homeostatic cancer cell system.
PloS one - 11 Aug 2010
Wegwitz Florian, Kluth Mark-Andreas, Mänz Claudia, Otto Benjamin, Gruner Katharina, Heinlein Christina, Kühl Marion, Warnecke Gabriele, Schumacher Udo, Deppert Wolfgang, Tolstonog Genrich V
Abstract excerpt
BACKGROUND: In analogy to normal stem cell differentiation, the current cancer stem cell (CSC) model presumes a hierarchical organization and an irreversible differentiation in tumor tissue. Accordingly, CSCs should comprise only a small subset of the tumor cells, which feeds tumor growth. However, some recent findings raised doubts on the general applicability of the CSC model and asked for its refinement....
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