Article
A functional interaction between the C-terminal domain of RNA polymerase II and the negative regulator SIN1.
Cell - 22 Mar 1991
Peterson C L, Kruger W, Herskowitz I
Abstract excerpt
The C-terminal domain (CTD) of the largest subunit of yeast RNA polymerase II contains 26-27 tandem copies of a conserved heptapeptide of unknown function. Yeast strains whose CTD contains ten heptamers are viable but defective for transcription of the INO1 gene and cold sensitive for growth. Deletion of the SIN1 gene, which codes for a DNA-binding protein that negatively regulates HO transcription, restores INO1...
Topics
- Amino Acid Sequence
- Chromosome Deletion
- DNA-Binding Proteins
- Fungal Proteins
- Macromolecular Substances
- Molecular Sequence Data
- Mutation
- Myo-Inositol-1-Phosphate Synthase
- RNA Polymerase II
- Repetitive Sequences, Nucleic Acid