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Article

Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia.

Biological psychiatry - 1 Jan 2011

Tregellas Jason R, Tanabe Jody, Rojas Donald C, Shatti Shireen, Olincy Ann, Johnson Lynn, Martin Laura F, Soti Ferenc, Kem William R, Leonard Sherry, Freedman Robert

Abstract excerpt

BACKGROUND: 3-(2,4-dimethoxybenzylidene)-anabaseine (DMXB-A) is a partial agonist at α7 nicotinic acetylcholine receptors that has been evaluated clinically for treatment of schizophrenia. This study examined the effects of DMXB-A on default network activity as a biomarker for drug effects on pat...

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Source

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Identifiers

PMID: 20728875
DOI: 10.1016/j.biopsych.2010.07.004
PMCID: PMC3005969

Genes

CHRNA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20728875-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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