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Article

Acute effects of Δ9-tetrahydrocannabinol (THC) on resting state connectivity networks and impact of COMT genotype: A multi-site pharmacological fMRI study.

Drug and alcohol dependence - 1 Oct 2023

Pelgrim Teuntje A D, Ramaekers Johannes G, Wall Matthew B, Freeman Tom P, Bossong Matthijs G

Abstract excerpt

BACKGROUND: Cannabis produces various acute psychotropic effects, with marked individual differences. Cannabis use is a risk factor for developing psychotic disorders. The main component responsible for these effects is Δ9-tetrahydrocannabinol (THC). Here we investigated the neural basis of acute THC effects and its modulation by catechol-methyl-transferase (COMT) Val158Met genotype. METHODS: Resting state...

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PMID: 37598453
DOI: 10.1016/j.drugalcdep.2023.110925

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