Article

Translational Evidence for Dopaminergic Alteration of Basal Ganglia Functional Connectivity in Persons with Schizophrenia

2025-04-01

Abstract excerpt

In prior work, a transgenic mouse model of striatal dopamine dysfunction observed in persons with schizophrenia (PSZ) exhibited dopamine-related neuroplasticity in the basal ganglia, a phenotype that has never been demonstrated in human PSZ. Consequently, we sought to identify a dopamine-related alteration of basal ganglia connectivity via working memory task-based and resting-state functional magnetic resonance i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b9a622ab-bf91-573b-963b-b4b4a849770e
DOI: 10.1101/2025.03.31.25324962

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Translational Evidence for Dopaminergic Alteration of Basal Ganglia Functional Connectivity in Persons with SchizophreniaDOI 10.1101/2025.03.31.25324962Read

Dysfunctional brain networks and genetic risk for schizophrenia: specific neurotransmitter systems.Semantic proximity Read

Cholinergic circuit genes in the healthy brain are differentially expressed in regions that exhibit gray matter loss in Parkinson’s diseaseSemantic proximity Read

Prefronto-subcortical hypoconnectivity in schizophrenia: translation of critical pathways for symptom-related functions in nonhuman primatesSemantic proximity Read

Neuroimaging in Psychiatry: An OverviewSemantic proximity Read

NeuroMark-SZ: A Holistic Resting-State-fMRI-Based Model for Divergent Functional Circuitry in SchizophreniaSemantic proximity Read

Neuroimaging Biomarkers in Parkinson's Disease: Current Applications and Future DirectionsSemantic proximity Read

Resting-state brain functional alterations and their genetic mechanisms in drug-naive first-episode psychosisSemantic proximity Read

Network-based Molecular Constraints on in vivo Synaptic Density Alterations in SchizophreniaSemantic proximity Read

Normative Modelling of Molecular-based Functional Neurocircuits Captures Clinical Heterogeneity Transdiagnostically in Neuropsychiatric PatientsSemantic proximity Read

Mapping Neurochemical Signatures onto Brain Structure for Neurotransmitter-Informed Discrimination of Schizophrenia Patients from Healthy ControlsSemantic proximity Read

Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory.Semantic proximity Read

Effective connectivity of AKT1-mediated dopaminergic working memory networks and pharmacogenetics of anti-dopaminergic treatment.Semantic proximity Read