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Article

Human leptin tissue distribution, but not weight loss-dependent change in expression, is associated with methylation of its promoter

1 Oct 2011

Abstract excerpt

Leptin is a master regulator of energy homeostasis. Its expression, prevalently localized in adipocytes, is positively related to adipose mass. Epigenetics is emerging as an important contributor to the changes in gene expression undergone by adipose tissue during obesity. We herein investigated the involvement of methylation-dependent mechanisms in leptin regulation in humans. We studied the methylation profile...

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Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Epigenetics and DNA Methylation
Share to Regulation of Appetite and Obesity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21931275
DOI: 10.4161/epi.6.10.16600

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