Article
A functional varient in microRNA-146a is associated with risk of esophageal squamous cell carcinoma in Chinese Han.
Familial cancer - 1 Dec 2010
Guo Hong, Wang Kai, Xiong Gang, Hu Huamei, Wang Dongmei, Xu Xueqing, Guan Xingying, Yang Kang, Bai Yun
Abstract excerpt
MicroRNAs are a new class of non-proteincoding, small RNAs that function as tumor suppressors or oncogenes. They participate in diverse biological pathways and function as gene regulators. A G>C polymorphism (rs2910164), which is located in the sequence of miR-146a precursor, results in a change from G:U to C:U in its stem region. However, it remains largely unknown whether this single nucleotide polymorphism...
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