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Function of human Rh based on structure of RhCG at 2.1 Å

8 May 2010

Abstract excerpt

In humans, NH(3) transport across cell membranes is facilitated by the Rh (rhesus) family of proteins. Human Rh C glycoprotein (RhCG) forms a trimeric complex that plays an essential role in ammonia excretion and renal pH regulation. The X-ray crystallographic structure of human RhCG, determined at 2.1 A resolution, reveals the mechanism of ammonia transport. Each monomer contains 12 transmembrane helices, one...

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PMID: 20457942
DOI: 10.1073/pnas.1003587107

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