Article
Altered DNA repair capacity and bleomycin sensitivity as risk markers for non-small cell lung cancer.
International journal of cancer - 20 Mar 2001
Rajaee-Behbahani N, Schmezer P, Risch A, Rittgen W, Kayser K W, Dienemann H, Schulz V, Drings P, Thiel S, Bartsch H
Abstract excerpt
DNA repair capacity in human peripheral blood lymphocytes was monitored by the repair rate of bleomycin-induced DNA damage using an alkaline single-cell gel electrophoresis assay (comet assay). DNA repair capacity, after 15 min repair time, in lymphocytes of non-small cell lung cancer patients (n = 160) and controls (n = 180) was 67% and 79.3%, respectively (p < 0.0004). Bleomycin sensitivity defined as the tail...
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