Article
Repair of oxidative DNA damage: assessing its contribution to cancer prevention.
Mutagenesis - 1 Nov 2002
Collins Andrew, Harrington Vikki
Abstract excerpt
DNA repair is a crucial factor in maintaining a low steady-state level of oxidative DNA damage and protecting us from cancer. Cancer case-control studies, using indirect assays in which chromosome breakage in lymphocytes is taken as a measure of failure to repair DNA, indicate an association between poor repair and cancer risk, but case-control studies can be misleading. Surprisingly little is known of the...
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