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Article

Detectability of Plasmodium falciparum clones.

Malaria journal - 18 Aug 2010

Bretscher Michael T, Valsangiacomo Francesca, Owusu-Agyei Seth, Penny Melissa A, Felger Ingrid, Smith Tom

Abstract excerpt

BACKGROUND: In areas of high transmission people often harbour multiple clones of Plasmodium falciparum, but even PCR-based diagnostic methods can only detect a fraction (the detectability, q) of all clones present in a host. Accurate measurements of detectability are desirable since it affects estimates of multiplicity of infection, prevalence, and frequency of breakthrough infections in clinical drug trials....

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Identifiers

PMID: 20718959
DOI: 10.1186/1475-2875-9-234
PMCID: PMC2936403

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