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Article

The transglutaminase 2 gene is aberrantly hypermethylated in glioma.

Journal of neuro-oncology - 1 Feb 2011

Dyer Lisa M, Schooler Kevin P, Ai Lingbao, Klop Corinne, Qiu Jingxin, Robertson Keith D, Brown Kevin D

Abstract excerpt

Transglutaminase 2 (TG2) is a ubiquitously expressed protein that catalyzes protein/protein crosslinking. Because extracellular TG2 crosslinks components of the extracellular matrix, TG2 is thought to function as a suppressor of cellular invasion. We have recently uncovered that the TG2 gene (TGM2) is a target for epigenetic silencing in breast cancer, highlighting a molecular mechanism that drives reduced TG2...

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Source

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Identifiers

PMID: 20596752
DOI: 10.1007/s11060-010-0277-7
PMCID: PMC3019272

Genes

TGM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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