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Article

Mutation of the cellular adhesion molecule NECL2 is associated with neuromyelitis optica spectrum disorder.

Journal of the neurological sciences - 15 May 2018

Xu Yan, Li Liang, Ren Hai-Tao, Yin Bin, Yuan Jian-Gang, Peng Xiao-Zhong, Qiang Bo-Qin, Cui Li-Ying

Abstract excerpt

AIMS: To investigate the association of the Nectin/Necl family genes with the risk of developing NMOSD. METHODS: Whole-exome sequencing was performed on two familial NMOSD cases and two unaffected family members. Additionally, 106 patients with sporadic NMOSD and 212 healthy controls (HCs) underwent screening for mutant Necl2. Finally, the molecular weight and cellular localization of mutant NECL2 was examined in...

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PMID: 29627007
DOI: 10.1016/j.jns.2017.10.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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