Article
IL28B polymorphisms of both recipient and donor cooperate to influence IFN treatment response in HCV recurrence after liver transplantation, but IL28B SNPs of the recipient play a major role in IFN-induced blocking of HCV replication.
The new microbiologica - 1 Apr 2015
Barbera Floriana, Russelli Giovanna, Pipitone Loredana, Pietrosi Giada, Corsale Sveva, Vizzini Giovanni, Gridelli Bruno, Conaldi Pier Giulio
Abstract excerpt
Single nucleotide polymorphisms (SNPs) of the IL28B locus are associated with a positive response to pegylated interferon-alpha and ribavirin (pegIFN-alpha/RBV) treatment of HCV-infected patients. This study evaluated the association between SNPs rs12980275, rs12979860 and rs8099917 and treatment outcome of HCV recurrent infection in HCV-positive patients who underwent liver transplant. We aimed to assess to what...
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