Article
Loss of zinc finger MYND-type containing 10 (zmynd10) affects cilia integrity and axonemal localization of dynein arms, resulting in ciliary dysmotility, polycystic kidney and scoliosis in medaka (Oryzias latipes).
Developmental biology - 1 Oct 2017
Kobayashi Daisuke, Asano-Hoshino Anshin, Nakakura Takashi, Nishimaki Toshiyuki, Ansai Satoshi, Kinoshita Masato, Ogawa Motoyuki, Hagiwara Haruo, Yokoyama Takahiko
Abstract excerpt
Cilia and flagella are hair-like organelles that project from the cell surface and play important roles in motility and sensory perception. Motility defects in cilia and flagella lead to primary ciliary dyskinesia (PCD), a rare human disease. Recently zinc finger MYND-type containing 10 (ZMYND10) was identified in humans as a PCD-associated gene. In this study, we use medaka fish as a model to characterize the...
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